The purpose of this FOA is to support the development of chemical probes that aid basic research investigations on substance use disorders (SUDs) or identify new lead chemical scaffolds with potential for structure activity relationship (SAR) studies on SUDs. In the long term, it is hoped that these lead chemical scaffolds will provide a greater number of pharmacological tools for basic research and possible drug candidates for medications development.

Applicant and host information

Applicant citizenship: United States

Host country: United States

Years since PhD:

Award details

Award: $750 000

Award Duration (years): 4

Research costs:


Mobility rule:

Subjects: Pharmacology, Toxicology and Environmental Health

Additional comments: This announcement is intended to encourage early career chemists (or chemists new to NIH) to develop probes that aid basic research investigations on drug abuse and/or identify new or better templates as lead compounds with potential for conducting structure activity relationship (SAR)-function studies. Importantly, this includes the identification of new chemical entities (NCEs) with therapeutic potential for drug abuse and addiction. Applicants responding to this FOA should explain their rationale for the proposed work, the inclusion of pharmacologic assessments, and the relationship of the research proposed in the context of a broader medications development pipeline (e.g., Target Identification > Probe/ligand screening > Synthesis of ligands > Assay development > Proof of concept > Lead optimization, etc.). A New Investigator is an NIH research grant applicant who may not yet have competed successfully for a substantial, NIH research grant. For example, a PD/PI who has previously received a competing NIH R01 research grant is no longer considered a New Investigator. However, a PD/PI who has received a small grant (R03) or an Exploratory, Developmental Research Grant Award (R21) retains his or her status as a New Investigator. For the R21 award, direct costs are limited to $250,000 over a two-year period, with a maximum of $200,000 allowed in any single year. The R33 award will be limited to $250,000 in direct costs per year.

How to apply? For further eligibility requirements and the application process, please visit: Official Funding website

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Application deadline

February 16, June 16, October 16
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This entry has been last updated: 2020-05-24 13:29:49

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